[Abstract]:

On November 3, at the 59th China International Pharmaceutical Machinery Expo, TIANS held a summit forum on "full life cycle design, automation and environmental protection of characteristic API plants". Focusing on the characteristic API project, TIANS process design expert Zhou LanXia, automatic control technology expert Yue ZongLi and wastewater treatment expert Ma ZhongQing introduced the characteristics and development trend of characteristic API workshop In terms of environmental protection, combined with specific cases, the application of electro catalytic oxidation technology in the purification of miscellaneous salts is introduced.

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primary coverage

01

Sharing and Discussion on design concept of characteristic API workshop

Characteristic API products have higher added value, and compared with bulk APIs, they have more stringent requirements in terms of quality and technology, higher barriers to entry, and higher profit margin, so they have become the sub category of API industry that is very concerned at present.

Through analysis and explanation, this course introduces the workshop characteristics, development trend, layout characteristics, workshop design points and core design concept of characteristic API; through analysis of the basic characteristics of API industry, it summarizes that in the construction process of characteristic API project, the construction unit and design unit should focus on: compliance requirements, multi-functional production and lean production There are four requirements in production, energy saving and consumption reduction.

Combined with the design cases and practical problems in TIANS for many years, this paper puts forward a series of core design concepts with reference value, such as flexible multi-function line, modularized function division, rationalized combination layout, water-saving, energy-saving and green, covering safety production, occupational health, environmental protection and fine design It has many aspects, such as planning, energy saving, automation, information and so on.

 

Zhou LanXia

Senior engineer, process design expert

Executive deputy general manager of TIANS Pharmaceutical Engineering Design Co., Ltd

Graduated from environmental engineering of Shandong University. It has won two second prizes of excellent engineering design at provincial and ministerial level. Is a senior engineer, process design experts, registered chemical engineer.

He has been engaged in process design of pharmaceutical and chemical industry for many years. His projects include pharmaceutical and chemical raw materials, sterile raw materials, fine chemicals, etc. Have the design ability to undertake complex projects independently, be able to solve complex technical problems within the scope of the specialty, and have rich design experience.

02

Automation solution for chemical synthetic API plant

Starting from the typical characteristics and implementation considerations of automation engineering solutions for chemical synthesis API factory: system scalability, process integration, control scheme implementation, operation and maintenance convenience of production workshop, specification compliance, professional engineering installation and reasonable cost control, the course is shared.

In terms of plant automation system planning and key automation system solutions, through the automation project of API synthesis workshop, from the aspects of process understanding, engineering experience, hardware supporting design, etc., this paper explains in detail how to solve many problems faced by chemical synthesis API factory through automation, and combines the solutions with the actual production characteristics and typical control units Solvent recovery, weighing and feeding management and other aspects of classification and analysis, and suit the remedy to the case; for the user management methods put forward normative explanation, let the participants more understand the operation and operation mode of the automation system.

Based on many years of experience in API automation project and the latest engineering cases, the lecturer introduced the importance of close integration of scheme and process, landing of scheme, convenient production operation and maintenance, expandability of system, compliance with specifications, and professional construction and installation in simple language .

 

Yue ZongLi

Senior engineer, automation technology expert

General manager of auto control division of TIANS Group

Graduated from Zhengzhou Institute of aeronautical industry management, majoring in electrical engineering and automation. He has rich experience in the implementation of chemical synthetic API production process automation and clean air conditioning automation project.

It has successively completed the chemical synthesis API multi-functional workshop automation project of Qilu pharmaceutical Leling Pharmaceutical Industrial Park Phase II project, cecep Wanrun Chemical Industrial Park Phase I project, Jiangxi Xiangtai Life Science Co., Ltd. chemical synthesis API workshop automation project, Shandong Jincheng biological cefuroxime acid synthesis workshop automation project and Chongqing Tiandi The first phase project of Wuyang Pharmaceutical Industrial Park of Pharmaceutical Co., Ltd. is the automation project of raw material drug synthesis workshop, and the first and second phase project of Chengdu micro core pharmaceutical innovative drug production base is the automation project of plant automation system planning and scheme design. The application design of solvent recovery automatic process control system and constant variable air volume valve in clean air conditioning under the leadership of the company has won the national patent.

03

Discussion on treatment process of high salinity and high concentration wastewater from chemical synthesis of API

Starting from the concept of system engineering, combined with the characteristics of high salinity and high COD wastewater, such as many drainage points, intermittent wastewater discharge, large collection tank for homogenization, high concentration and imbalance of carbon nitrogen ratio, several advanced pretreatment methods applied in actual production are elaborated through many years of industry experience and examples.

Based on cases and data, this paper introduces in detail the latest scientific research achievements of TIANS science and technology innovation center in this field: homogeneous photocatalytic oxidation technology, heterogeneous photocatalytic oxidation technology features and technology development process; key uses of ozone catalytic oxidation technology in the process of industrialization; and treatment of API wastewater with mature industrial technology It provides strong technical support.

This paper introduces and analyzes the environmental protection related equipment developed by TIANS, such as molecular sieve, new continuous elimination equipment, etc. Through the combination of technology and equipment, TIANS helps API to further improve its wastewater treatment capacity and green manufacturing level.

 

Ma ZhongQing

Senior engineer, wastewater treatment expert, pharmaceutical technology expert

Deputy general manager of environmental protection department of TIANS Group

He graduated from Hebei University of technology with a bachelor's degree in fine chemical engineering. Focus on refining process optimization design, fermentation product separation and purification process design, solvent recovery process design, the best equipment supporting scheme.

Presided over and participated in the CHUANNING biological environmental protection project in Xinjiang. He has deep research and rich engineering experience in VOCs waste gas treatment technology and sludge dewatering technology in pharmaceutical industry.

He has won the first prize of Hebei Province Science and technology progress, and 6-APA new production process has won the science and technology achievement award of Hebei Provincial Department of technology. He has published articles such as "improvement of synthetic process of roxithromycin" and "improvement of closed circulation of working fluid of water ring vacuum pump". He has deep attainments in the combination of antibiotic production process and equipment, membrane technology separation and other professional fields, and has rich experience in large-scale antibiotic engineering construction.